Immunogenic HIV variant peptides that bind to HLA-B8 can fail to stimulate cytotoxic T lymphocyte responses.

Cytotoxic T lymphocyte responses in HIV infection can be impaired through variation in the epitope regions of viral proteins such as a gag. We report here an analysis of variant epitope peptides in three gag epitopes presented by HLA B8. Fifteen variant peptides were examined for their binding to HL...

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Detalhes bibliográficos
Main Authors: McAdam, S, Klenerman, P, Tussey, L, Rowland-Jones, S, Lalloo, D, Phillips, R, Edwards, A, Giangrande, P, Brown, A, Gotch, F
Formato: Journal article
Idioma:English
Publicado em: 1995