Mutations of NFKBIA, encoding IkappaB alpha, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases.

Mutations of NFKBIA, encoding IkappaB alpha, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases.

A consistent feature of the Hodgkin and Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL) is the constitutive activation of NF-kappaB transcription factors. In Epstein-Barr virus (EBV)-associated cases of cHL, expression of viral antigens most probably leads to NF-kappaB activation but...

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Bibliographic Details
Main Authors: Lake, A, Shield, L, Cordano, P, Chui, D, Osborne, J, Crae, S, Wilson, K, Tosi, S, Knight, S, Gesk, S, Siebert, R, Hay, RT, Jarrett, R
Format: Journal article
Language:English
Published: 2009

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