Inhibiting HLA-B27 homodimer-driven immune cell inflammation in spondylarthritis.

OBJECTIVE: Spondylarthritides (SpA), including ankylosing spondylitis (AS), are common inflammatory rheumatic diseases that are strongly associated with positivity for the HLA class I allotype B27. HLA-B27 normally forms complexes with β(2) -microglobulin (β(2) m) and peptide to form heterotrimers....

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Bibliographic Details
Main Authors: Payeli, S, Kollnberger, S, Marroquin Belaunzaran, O, Thiel, M, McHugh, K, Giles, J, Shaw, J, Kleber, S, Ridley, A, Wong-Baeza, I, Keidel, S, Kuroki, K, Maenaka, K, Wadle, A, Renner, C, Bowness, P
Format: Journal article
Language:English
Published: 2012