Inhibiting HLA-B27 homodimer-driven immune cell inflammation in spondylarthritis.
OBJECTIVE: Spondylarthritides (SpA), including ankylosing spondylitis (AS), are common inflammatory rheumatic diseases that are strongly associated with positivity for the HLA class I allotype B27. HLA-B27 normally forms complexes with β(2) -microglobulin (β(2) m) and peptide to form heterotrimers....
Main Authors: | , , , , , , , , , , , , , , , |
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Format: | Journal article |
Language: | English |
Published: |
2012
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