The role of catechol-O-methyltransferase in reward processing and addiction.

The role of catechol-O-methyltransferase in reward processing and addiction.

Catechol-O-methyltransferase (COMT) catabolises dopamine and is important for regulating dopamine levels in the prefrontal cortex. Consistent with its regulation of prefrontal cortex dopamine, COMT modulates working memory and executive function; however, its significance for other cognitive domains...

Full description

Bibliographic Details
Main Authors:	Tunbridge, E, Huber, A, Farrell, S, Stumpenhorst, K, Harrison, P, Walton, M
Format:	Journal article
Language:	English
Published:	2012

Similar Items

Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest.
by: Tunbridge, E, et al.
Published: (2013)

INVESTIGATION OF THE ROLE OF CATECHOL-O-METHYLTRANSFERASE(COMT) ON HIPPOCAMPUS-DEPENDENT BEHAVIOUR
by: Laatikainen, L, et al.
Published: (2010)

Separate and interactive effects of catechol-o-methyltransferase and tetrahydrocannabinol on frontostriatal dopamine function
by: Stumpenhorst, K
Published: (2017)

The magnetoencephalographic signature of catechol-O-methyltransferase
by: Farrell, SM
Published: (2013)

The catechol-O-methyltransferase gene: its regulation and polymorphisms.
by: Tunbridge, E
Published: (2010)

The Role of Catechol-O-Methyltransferase (COMT) in Modulating Hippocampal Dopaminergic Metabolism and Behaviour
by: Laatikainen, L, et al.
Published: (2010)

Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond.
by: Tunbridge, E, et al.
Published: (2006)

COMT Val(158)Met genotype determines the direction of cognitive effects produced by catechol-O-methyltransferase inhibition.
by: Farrell, S, et al.
Published: (2012)

Catechol-O-methyltransferase activity does not influence emotional processing in men
by: Martens, MA, et al.
Published: (2022)

The role of catechol-O-methyltransferase in processing affective stimuli
by: Dalton, N
Published: (2016)

metabolism and hippocampal-dependent cognitive function by catechol-O-methyltransferase inhibition
by: Laatikainen, L, et al.
Published: (2012)

Catechol-o-methyltransferase (COMT) influences dopamine metabolism outside of the prefrontal cortex
by: Laatikainen, L, et al.
Published: (2011)

Expression and functional impact of multiple catechol-o-methyltransferase (COMT) mRNA variants
by: Lane, T, et al.
Published: (2007)

Expression of multiple catechol-o-methyltransferase (COMT) mRNA variants in human brain.
by: Tunbridge, E, et al.
Published: (2007)

Detection and expression of multiple catechol-o-methyltransferase mRNA variants in human brain
by: Tunbridge, E, et al.
Published: (2007)

The role of catechol-O-methyltransferase (COMT) in hippocampal function
by: Laatikainen, L
Published: (2010)

Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levels.
by: Tunbridge, E, et al.
Published: (2008)

Effects of catechol-o-methyltransferase on reinforcement learning and mesolimbic dopamine transmission
by: Huber, A
Published: (2015)

Modulation of hippocampal dopamine metabolism and hippocampal-dependent cognitive function by catechol-O-methyltransferase inhibition.
by: Laatikainen, L, et al.
Published: (2012)

Sexually dimorphic effects of catechol-O-methyltransferase (COMT) inhibition on dopamine metabolism in multiple brain regions
by: Laatikainen, L, et al.
Published: (2013)

Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders.
by: Harrison, P, et al.
Published: (2008)

Human plasma homocysteine levels are associated with the catechol-O-methyltransferase Val158Met polymorphism
by: Tunbridge, E, et al.
Published: (2007)

A novel variant of catechol-O-methyltransferase increased in schizophrenia and bipolar disorder and associated with val(158)met genotype
by: Tunbridge, E, et al.
Published: (2005)

Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex.
by: Tunbridge, E, et al.
Published: (2004)

Catechol-O-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex
by: Tunbridge, E, et al.
Published: (2004)

Catechol-o-methyltransferase enzyme activity and protein expression in human prefrontal cortex across the postnatal lifespan.
by: Tunbridge, E, et al.
Published: (2007)

Catechol-o-methyltransferase (COMT) and proline dehydrogenase (PRODH) mRNAs in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression.
by: Tunbridge, E, et al.
Published: (2004)

A novel protein isoform of catechol O-methyltransferase (COMT): brain expression analysis in schizophrenia and bipolar disorder and effect of Val158Met genotype.
by: Tunbridge, E, et al.
Published: (2006)

Computational Investigation of the Interplay of Substrate Positioning and Reactivity in Catechol O-Methyltransferase
by: Patra, Niladri, et al.
Published: (2016)

Dissociative catecholaminergic modulation of visual attention: Differential effects of Catechol-O-methyltransferase and dopamine beta-hydroxylase genes on visual attention
by: Shalev, N, et al.
Published: (2019)

Neuregulin1-induced cell migration is impaired in schizophrenia: association with neuregulin1 and catechol-o-methyltransferase gene polymorphisms.
by: Sei, Y, et al.
Published: (2007)

Catechol-o-methyltransferse (COMT) inhibition improves set shifting performance in the rat
by: Tunbridge, E, et al.
Published: (2004)

How Large Should the QM Region Be in QM/MM Calculations? The Case of Catechol O-Methyltransferase
by: Zhang, Jianyu, et al.
Published: (2017)

Association study between catechol-O-methyltransferase polymorphisms and uterine leiomyomas in a Japanese population.
by: Morikawa, J, et al.
Published: (2008)

Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models.
by: Sei, Y, et al.
Published: (2010)

The met(158) allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case-control study and meta-analysis.
by: Pooley, E, et al.
Published: (2007)

Association of the functional polymorphism in the catechol-O-methyltransferase gene with schizophrenia in the three ethnic groups of the Malaysian population
by: Wan, C.L., et al.
Published: (2011)

The Catechol-O-Methyltransferase (COMT) val158met Polymorphism Affects Brain Responses to Repeated Painful Stimuli
by: Loggia, Marco L., et al.
Published: (2012)

Editorial: Memory systems of the addicted brain: The underestimated role of cognitive biases in addiction and its treatment
by: David, V, et al.
Published: (2018)

Allelic and genotype frequencies of catechol-O-methyltransferase (Val158Met) and CYP2D6*10 (Pro34Ser) single nucleotide polymorphisms in the Philippines.
by: Baclig, M, et al.
Published: (2012)