The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor.
The selective non-competitive NMDA receptor antagonist, MK-801, potently blocked convulsions induced in the mouse by N-methyl-DL-aspartic acid (NMDLA) with an i.v. ED50 dose of 0.2 mg/kg. Similar doses of MK-801 were also effective in blocking seizures induced by pentylenetetrazol (PTZ), electroshoc...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1989
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