Crystal structures of VIM‐1 complexes explain active site heterogeneity in VIM‐class metallo‐β‐lactamases

Metallo‐β‐Lactamases (MBLs) protect bacteria from almost all β‐lactam antibiotics. Verona integron‐encoded MBL (VIM) enzymes are among the most clinically important MBLs, with VIM‐1 increasing in carbapenem‐resistant Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae) that are among the har...

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Bibliographic Details
Main Authors: Salimraj, R, Hinchliffe, P, Kosmopoulou, M, Tyrrell, J, Brem, J, Van Berkel, S, Verma, A, Owens, R, McDonough, M, Walsh, T, Schofield, C, Spencer, J
Format: Journal article
Language:English
Published: FEBS Press 2018