Crystal structures of VIM‐1 complexes explain active site heterogeneity in VIM‐class metallo‐β‐lactamases

Metallo‐β‐Lactamases (MBLs) protect bacteria from almost all β‐lactam antibiotics. Verona integron‐encoded MBL (VIM) enzymes are among the most clinically important MBLs, with VIM‐1 increasing in carbapenem‐resistant Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae) that are among the har...

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Detalhes bibliográficos
Principais autores: Salimraj, R, Hinchliffe, P, Kosmopoulou, M, Tyrrell, J, Brem, J, Van Berkel, S, Verma, A, Owens, R, McDonough, M, Walsh, T, Schofield, C, Spencer, J
Formato: Journal article
Idioma:English
Publicado em: FEBS Press 2018