Structural evolution of p53, p63, and p73: implication for heterotetramer formation.

Structural evolution of p53, p63, and p73: implication for heterotetramer formation.

Oligomerization of members of the p53 family of transcription factors (p53, p63, and p73) is essential for their distinct functions in cell-cycle control and development. To elucidate the molecular basis for tetramer formation of the various family members, we solved the crystal structure of the hum...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs:	Joerger, A, Rajagopalan, S, Natan, E, Veprintsev, D, Robinson, C, Fersht, A
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	2009

Gelijkaardige items

P63 and P73 Activation in Cancers with p53 Mutation
door: Bi-He Cai, et al.
Gepubliceerd in: (2022-06-01)

Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration.
door: Arbely, E, et al.
Gepubliceerd in: (2011)

Interaction of the p53 DNA-binding domain with its n-terminal extension modulates the stability of the p53 tetramer.
door: Natan, E, et al.
Gepubliceerd in: (2011)

A família do p53: aspectos estruturais e funcionais do p73 e do p63 The p53 family: structural and functional aspects of p73 and p63
door: Alfredo Ribeiro-Silva, et al.
Gepubliceerd in: (2003-06-01)

Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73.
door: Robinson, R, et al.
Gepubliceerd in: (2008)

Ultraslow oligomerization equilibria of p53 and its implications.
door: Natan, E, et al.
Gepubliceerd in: (2009)

Oncogenic p53 triggers amyloid aggregation of p63 and p73 liquid droplets
door: Elaine C. Petronilho, et al.
Gepubliceerd in: (2024-09-01)

The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complex.
door: Lakshmanane Boominathan
Gepubliceerd in: (2010-05-01)

Stability of p53 homologs.
door: Tobias Brandt, et al.
Gepubliceerd in: (2012-01-01)

Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization.
door: Gebel, J, et al.
Gepubliceerd in: (2016)

Dynamic expression of the p53 family members p63 and p73 in the mouse and human telencephalon during development and in adulthood.
door: Hernández-Acosta, N, et al.
Gepubliceerd in: (2011)

Dynamic expression of the p53 family members p63 and p73 in the mouse and human telencephalon during development and in adulthood
door: Hernández-Acosta, N, et al.
Gepubliceerd in: (2011)

Functional regulation of p73 and p63: development and cancer.
door: Melino, G, et al.
Gepubliceerd in: (2003)

Intrinsically disordered p53 and its complexes populate compact conformations in the gas phase.
door: Pagel, K, et al.
Gepubliceerd in: (2013)

Rescuing the function of mutant p53.
door: Bullock, A, et al.
Gepubliceerd in: (2001)

p63 and p73 Transcriptionally Regulate Genes Involved in DNA Repair
door: Lin, Yu-Li, et al.
Gepubliceerd in: (2010)

DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma
door: Alexander Strubel, et al.
Gepubliceerd in: (2023-10-01)

Retraction: p63 and p73 Transcriptionally Regulate Genes Involved in DNA Repair.
door: PLOS Genetics Editors
Gepubliceerd in: (2023-03-01)

EXPRESSION OF p53 AND p63 IN CERVICAL SQUAMOUS CELL CARCINOMA
door: , ILHAMI ROMUS, et al.
Gepubliceerd in: (2013)

Immunohistochemical expression of p63, p53 in urinary bladder carcinoma
door: Ali Koyuncuer
Gepubliceerd in: (2013-01-01)

p73 and p63 sustain cellular growth by transcriptional activation of cell cycle progression genes.
door: Lefkimmiatis, K, et al.
Gepubliceerd in: (2009)

Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators
door: Dimitrios-Ilias Balourdas, et al.
Gepubliceerd in: (2024-06-01)

Strategies to Discover p53 Activators and a p73 Activator for Neuroblastoma
door: Emília Sousa, et al.
Gepubliceerd in: (2019-08-01)

MDM2 and MDMX bind and stabilize the p53-related protein p73
door: Ongkeko, W, et al.
Gepubliceerd in: (1999)

Effect of hydroxyurea on the promoter occupancy profiles of tumor suppressor p53 and p73
door: Lu Xin, et al.
Gepubliceerd in: (2009-06-01)

Proinflammatory cytokines and bile acids upregulate ΔNp73 protein, an inhibitor of p53 and p73 tumor suppressors.
door: Elena Zaika, et al.
Gepubliceerd in: (2013-01-01)

Expression of p63, p53 and Ki-67 in Patients with Cervical Intraepithelial Neoplasia
door: Androniks MITILDZANS, et al.
Gepubliceerd in: (2017-01-01)

Dissecting the DNA binding landscape and gene regulatory network of p63 and p53
door: Konstantin Riege, et al.
Gepubliceerd in: (2020-12-01)

p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis.
door: Bergamaschi, D, et al.
Gepubliceerd in: (2003)

Specific recognition of p53 tetramers by peptides derived from p53 interacting proteins.
door: Ronen Gabizon, et al.
Gepubliceerd in: (2012-01-01)

A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo.
door: Bell, H, et al.
Gepubliceerd in: (2007)

Inactivation of the KcsA potassium channel explored with heterotetramers.
door: Rotem, D, et al.
Gepubliceerd in: (2010)

Distinct p63 and p73 Protein Interactions Predict Specific Functions in mRNA Splicing and Polyploidy Control in Epithelia
door: Julian M. Rozenberg, et al.
Gepubliceerd in: (2020-12-01)

Evaluation of P53 and P63 expression and their correlation with HPV virus in oral dysplastic lesions
door: Fatemeh Mashhadi Abbas, et al.
Gepubliceerd in: (2012-01-01)

Revisiting the Dimensions of Knowledge Management Orientation Behavior in Indonesia Creative Industry (P.63-73)
door: Ananda Sabil Hussein, et al.
Gepubliceerd in: (2017-02-01)

Assessment and comparison of p53 and p63 expression in oral epithelial dysplasia and squamous cell carcinoma
door: Smitha Sammith Shetty, et al.
Gepubliceerd in: (2014-01-01)

Association of combined p73 and p53 genetic variants with tumor HPV16-positive oropharyngeal cancer.
door: Zhongqiu Wang, et al.
Gepubliceerd in: (2012-01-01)

Heterodimer-heterotetramer formation mediates enhanced sensor activity in a biophysical model for BMP signaling.
door: Md Shahriar Karim, et al.
Gepubliceerd in: (2021-09-01)

Immunohistochemical analysis of dentigerous cyst and ameloblastoma using cytokeratin 19 & 14, p53, p63 and ki-67
door: K Sudheer Kanth, et al.
Gepubliceerd in: (2012-01-01)

Expression of p53, p63, podoplanin and Ki-67 in recurring versus non-recurring oral leukoplakia
door: Jonas Sundberg, et al.
Gepubliceerd in: (2021-10-01)