Structural evolution of p53, p63, and p73: implication for heterotetramer formation.

Structural evolution of p53, p63, and p73: implication for heterotetramer formation.

Oligomerization of members of the p53 family of transcription factors (p53, p63, and p73) is essential for their distinct functions in cell-cycle control and development. To elucidate the molecular basis for tetramer formation of the various family members, we solved the crystal structure of the hum...

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Những tác giả chính:	Joerger, A, Rajagopalan, S, Natan, E, Veprintsev, D, Robinson, C, Fersht, A
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	2009

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