Thiophene-fused γ-lactams inhibit the SARS-CoV-2 main protease via reversible covalent acylation
<p>Enzyme inhibitors working by <em>O</em>-acylation of nucleophilic serine residues are of immense medicinal importance, as exemplified by the β-lactam antibiotics. By contrast, inhibition of nucleophilic cysteine enzymes by <em>S</em>-acylat...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2024
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