Thiophene-fused γ-lactams inhibit the SARS-CoV-2 main protease via reversible covalent acylation

<p>Enzyme inhibitors working by&nbsp;<em>O</em>-acylation of nucleophilic serine residues are of immense medicinal importance, as exemplified by the &beta;-lactam antibiotics. By contrast, inhibition of nucleophilic cysteine enzymes by&nbsp;<em>S</em>-acylat...

সম্পূর্ণ বিবরণ

গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Gayatri, Brewitz, L, Ibbotson, L, Salah, E, Basak, S, Choudhry, H, Schofield, CJ
বিন্যাস: Journal article
ভাষা:English
প্রকাশিত: Royal Society of Chemistry 2024