The role of BET attenuation in melanoma

The role of BET attenuation in melanoma

Bromodomain and extra-terminal (BETs) proteins function as epigenetic readers by docking onto acetylated lysine residues (Kac) on histone tails via tandem bromodomains (BRDs), and recruiting protein binding partners via an extra-terminal recruitment domain (ET). Targeting BET BRDs is efficacious in...

Полное описание

Библиографические подробности
Главный автор:	Henderson, EK
Другие авторы:	Filippakopoulos, P
Формат:	Диссертация
Язык:	English
Опубликовано:	2020
Предметы:	Melanoma p53 Cancer Skin cancer Prostate cancer BET proteins

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