Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination
PRR (pattern-recognition receptor) signalling is involved early in the immune response and therefore would be attractive to target during vaccination. The use of PRR ligands has shown some success; however, toxicity and non-specificity are issues with this strategy. The targeting of PRR intracellula...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1797074848559661056 |
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| author | Wales, J Andreakos, E Feldmann, M Foxwell, B |
| author_facet | Wales, J Andreakos, E Feldmann, M Foxwell, B |
| author_sort | Wales, J |
| collection | OXFORD |
| description | PRR (pattern-recognition receptor) signalling is involved early in the immune response and therefore would be attractive to target during vaccination. The use of PRR ligands has shown some success; however, toxicity and non-specificity are issues with this strategy. The targeting of PRR intracellular signalling networks would allow for greater specificity and reduced systemic toxicity. The present review examines the successes seen with overexpression or repression of PRR signalling molecules. ©The Authors. |
| first_indexed | 2024-03-06T23:42:09Z |
| format | Journal article |
| id | oxford-uuid:6fb1d51f-3284-4fe7-97e3-60d86c85caaa |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:42:09Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:6fb1d51f-3284-4fe7-97e3-60d86c85caaa2022-03-26T19:32:13ZTargeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccinationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6fb1d51f-3284-4fe7-97e3-60d86c85caaaEnglishSymplectic Elements at Oxford2007Wales, JAndreakos, EFeldmann, MFoxwell, BPRR (pattern-recognition receptor) signalling is involved early in the immune response and therefore would be attractive to target during vaccination. The use of PRR ligands has shown some success; however, toxicity and non-specificity are issues with this strategy. The targeting of PRR intracellular signalling networks would allow for greater specificity and reduced systemic toxicity. The present review examines the successes seen with overexpression or repression of PRR signalling molecules. ©The Authors. |
| spellingShingle | Wales, J Andreakos, E Feldmann, M Foxwell, B Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination |
| title | Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination |
| title_full | Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination |
| title_fullStr | Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination |
| title_full_unstemmed | Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination |
| title_short | Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination |
| title_sort | targeting intracellular mediators of pattern recognition receptor signalling to adjuvant vaccination |
| work_keys_str_mv | AT walesj targetingintracellularmediatorsofpatternrecognitionreceptorsignallingtoadjuvantvaccination AT andreakose targetingintracellularmediatorsofpatternrecognitionreceptorsignallingtoadjuvantvaccination AT feldmannm targetingintracellularmediatorsofpatternrecognitionreceptorsignallingtoadjuvantvaccination AT foxwellb targetingintracellularmediatorsofpatternrecognitionreceptorsignallingtoadjuvantvaccination |