Carcinomas contain a matrix metalloproteinase-resistant isoform of type I collagen exerting selective support to invasion.

Collagen fibers affect metastasis in two opposing ways, by supporting invasive cells but also by generating a barrier to invasion. We hypothesized that these functions might be performed by different isoforms of type I collagen. Carcinomas are reported to contain alpha1(I)(3) homotrimers, a type I c...

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Hlavní autoři: Makareeva, E, Han, S, Vera, J, Sackett, D, Holmbeck, K, Phillips, C, Visse, R, Nagase, H, Leikin, S
Médium: Journal article
Jazyk:English
Vydáno: 2010