Cell- and protein-directed glycosylation of native cleaved HIV-1 envelope

The gp120/gp41 HIV-1 envelope glycoprotein (Env) is highly glycosylated, with up to 50% of its mass consisting of N-linked glycans. This dense carbohydrate coat has emerged as a promising vaccine target, with its glycans acting as epitopes for a number of potent and broadly neutralizing antibodies (...

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Bibliographic Details
Main Authors: Pritchard, L, Harvey, D, Bonomelli, C, Crispin, M, Doores, K
Other Authors: Kirchhoff, F
Format: Journal article
Language:English
Published: American Society for Microbiology 2015