Molecular mechanisms of dysfunction of muscle fibres associated with Glu139 deletion in TPM2 gene
Deletion of Glu139 in β-tropomyosin caused by a point mutation in TPM2 gene is associated with cap myopathy characterized by high myofilament Ca2+-sensitivity and muscle weakness. To reveal the mechanism of these disorders at molecular level, mobility and spatial rearrangements of actin, tropomyosin...
Hlavní autoři: | , , , , , , |
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Médium: | Journal article |
Jazyk: | English |
Vydáno: |
Nature Publishing Group
2017
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