Molecular mechanisms of dysfunction of muscle fibres associated with Glu139 deletion in TPM2 gene

Deletion of Glu139 in β-tropomyosin caused by a point mutation in TPM2 gene is associated with cap myopathy characterized by high myofilament Ca2+-sensitivity and muscle weakness. To reveal the mechanism of these disorders at molecular level, mobility and spatial rearrangements of actin, tropomyosin...

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Hlavní autoři: Borovikov, Y, Rysev, N, Karpicheva, O, Sirenko, V, Avrova, S, Piers, A, Redwood, C
Médium: Journal article
Jazyk:English
Vydáno: Nature Publishing Group 2017