Distinct conformational stability and functional activity of four highly homologous endonuclease colicins.

The family of conserved colicin DNases E2, E7, E8, and E9 are microbial toxins that kill bacteria through random degradation of the chromosomal DNA. In the present work, we compare side by side the conformational stabilities of these four highly homologous colicin DNases. Our results indicate that t...

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Bibliographic Details
Main Authors: van den Bremer, E, Keeble, A, Jiskoot, W, Spelbrink, R, Maier, C, van Hoek, A, Visser, A, James, R, Moore, G, Kleanthous, K, Heck, A
Format: Journal article
Language:English
Published: 2004