T cell costimulation by CD6 is dependent on bivalent binding of a GADS/SLP-76 complex
The cell surface receptor, CD6 regulates T cell activation in both an activating and inhibitory manner. The adaptor protein SLP-76 is recruited to the CD6 cytoplasmic phosphorylated Y662 residue during T cell activation, providing an activating signal to T cells. In this study, a biochemical approa...
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| Format: | Journal article |
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American Society for Microbiology
2017
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