Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms

Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms

Genome-wide association studies have revealed numerous risk loci associated with diverse diseases. However, identification of disease-causing variants within association loci remains a major challenge. Divergence in gene expression due to cis-regulatory variants in noncoding regions is central to di...

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Hlavní autoři: Claussnitzer, M, Dankel, SN, Klocke, B, Grallert, H, Glunk, V, Berulava, T, Lee, H, Oskolkov, N, Fadista, J, Ehlers, K, Wahl, S, Hoffmann, C, Qian, K, Rönn, T, Riess, H, Müller-Nurasyid, M, Bretschneider, N, Schroeder, T, Skurk, T, Horsthemke, B, Diagram+Consortium, Spieler, D, Klingenspor, M, Seifert, M, Kern, MJ, Mejhert, N, Dahlman, I, Hansson, O, Hauck, SM, Blüher, M, Arner, P, Groop, L, Illig, T, Suhre, K, Hsu, Y-H, Mellgren, G, Hauner, H, Laumen, H
Další autoři: Johnson, P
Médium: Journal article
Jazyk:English
Vydáno: Cell Press 2014

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