Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum.

Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum.

The immunodominant CD4 T cell epitope region, Th2R, of the circumsporozoite protein of Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that costimulation with naturally occurri...

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Bibliografiske detaljer
Main Authors: Plebanski, M, Flanagan, K, Lee, E, Reece, W, Hart, K, Gelder, C, Gillespie, G, Pinder, M, Hill, A
Format: Journal article
Sprog:English
Udgivet: 1999
Beskrivelse
Summary:The immunodominant CD4 T cell epitope region, Th2R, of the circumsporozoite protein of Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that costimulation with naturally occurring altered peptide ligands (APL) can induce a rapid change from IFNgamma production to the immunosuppressive mediator interleukin 10 (IL-10). This mechanism may contribute to the low levels of T cell responses observed to this pathogen in malaria-endemic areas.

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