The mouse Runx1 +23 hematopoietic stem cell enhancer confers hematopoietic specificity to both Runx1 promoters.
The transcription factor Runx1 plays a pivotal role in hematopoietic stem cell (HSC) emergence, and studies into its transcriptional regulation should give insight into the critical steps of HSC specification. Recently, we identified the Runx1 +23 enhancer that targets reporter gene expression to th...
Main Authors: | Bee, T, Ashley, E, Bickley, SR, Jarratt, A, Li, P, Sloane-Stanley, J, Göttgens, B, de Bruijn, M |
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פורמט: | Journal article |
שפה: | English |
יצא לאור: |
2009
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פריטים דומים
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THE RUNX1+23 ENHANCER IS ACTIVE IN CELLS WITH BOTH ENDOTHELIAL AND HEMATOPOIETIC CHARACTERISTICS DURING MOUSE DEVELOPMENTAL HEMATOPOIESIS
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Alternative Runx1 promoter usage in mouse developmental hematopoiesis.
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Hematopoietic stem cell emergence in the conceptus and the role of Runx1.
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An intronic Runx1 enhancer directs transcription to the emerging hematopoietic system of the mouse embryo
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Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer.
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יצא לאור: (2007)