APC mutations in FAP-associated desmoid tumours are non-random but not 'just right'.
Analysis of APC mutations in colonic and duodenal tumours from familial adenomatous polyposis (FAP) patients has shown that the site of the first hit, the germline mutation, can predict the type and position of the somatic mutation or 'second hit'. The two APC mutations are selected on the...
Κύριοι συγγραφείς: | Latchford, A, Volikos, E, Johnson, V, Rogers, P, Suraweera, N, Tomlinson, I, Phillips, R, Silver, A |
---|---|
Μορφή: | Journal article |
Γλώσσα: | English |
Έκδοση: |
2007
|
Παρόμοια τεκμήρια
-
Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation.
ανά: Sturt, N, κ.ά.
Έκδοση: (2004) -
Location in the large bowel influences the APC mutations observed in FAP adenomas.
ανά: Will, O, κ.ά.
Έκδοση: (2010) -
A novel exon duplication event leading to a truncating germ-line mutation of the APC gene in a familial adenomatous polyposis family.
ανά: McCart, A, κ.ά.
Έκδοση: (2006) -
Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP.
ανά: Suraweera, N, κ.ά.
Έκδοση: (2007) -
Mutational spectrum of <it>APC </it>and genotype-phenotype correlations in Greek FAP patients
ανά: Fountzilas George, κ.ά.
Έκδοση: (2010-07-01)