The oocyte activation factor, phospholipase C zeta (PLCζ): potential mechanisms of action and scope for human infertility treatment

<p>It is widely believed that the sperm-specific protein phospholipase C zeta (PLCζ) is released into the oocyte upon fusion and initiates calcium (Ca<sup>2+</sup>) oscillations which regulate oocyte activation. Reduced amounts, abnormal localisation patterns, and aberrant forms...