Conjugation of Folate via Gelonin Carbohydrate Residues Retains Ribosomal-inactivating Properties of the Toxin and Permits Targeting to Folate Receptor Positive Cells
<p style="text-align:justify;">Conjugation of folate to proteins permits receptor-mediated endocytosis via the folate receptor (FR) and delivery of the conjugate into the cytoplasm of cells. Since many cancers up-regulate the FR it has enabled the targeting of toxins to tumor cells r...
| Auteurs principaux: | , , , , |
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| Format: | Journal article |
| Publié: |
American Society for Biochemistry and Molecular Biology
2001
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