Conjugation of Folate via Gelonin Carbohydrate Residues Retains Ribosomal-inactivating Properties of the Toxin and Permits Targeting to Folate Receptor Positive Cells
<p style="text-align:justify;">Conjugation of folate to proteins permits receptor-mediated endocytosis via the folate receptor (FR) and delivery of the conjugate into the cytoplasm of cells. Since many cancers up-regulate the FR it has enabled the targeting of toxins to tumor cells r...
Главные авторы: | Atkinson, S, Bettinger, T, Seymour, L, Behr, J, Ward, C |
---|---|
Формат: | Journal article |
Опубликовано: |
American Society for Biochemistry and Molecular Biology
2001
|
Схожие документы
-
Functional coating of liposomes using a folate&ndash;polymer conjugate to target folate receptors
по: Watanabe K, и др.
Опубликовано: (2012-07-01) -
Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate‐mediated targeting in vitro and prolonged plasma circulation in vivo
по: Ward, C, и др.
Опубликовано: (2002) -
Investigation of folate-conjugated fluorescent silica nanoparticles for targeting delivery to folate receptor-positive tumors and their internalization mechanism
по: Yang H, и др.
Опубликовано: (2011-09-01) -
Balance your folate or the yin and yang of folate in hematopoiesis
по: Hartmut Geiger
Опубликовано: (2017-12-01) -
Folate and Cancer
по: Luciana Yuki Tomita PhD
Опубликовано: (2016-07-01)