Cation-directed enantioselective N-functionalization of pyrroles

A catalytic enantioselective N-functionalization of pyrroles has been developed. Imines formed in situ via condensation underwent cation-directed cyclization with complete N-regioselectivity. The cyclized products were obtained with enantiomeric ratios up to 96:4 for aldimine substrates and up to 99...

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Bibliographic Details
Main Authors: Armstrong, R, D'Ascenzio, M, Smith, M
Format: Journal article
Published: Thieme Publishing 2016