An aryne-based route to substituted benzoisothiazoles
The combination of arynes, generated using fluoride from the corresponding 2-(trimethylsilyl)aryl triflates, and 3-hydroxy-4-aminothiadiazoles leads to the selective formation of 3-amino-substituted benzo[d]isothiazoles. Variation of the substitution pattern of the aryne precursor, and of the thiadi...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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American Chemical Society
2015
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| _version_ | 1797111927022813184 |
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| author | Chen, Y Willis, MC |
| author_facet | Chen, Y Willis, MC |
| author_sort | Chen, Y |
| collection | OXFORD |
| description | The combination of arynes, generated using fluoride from the corresponding 2-(trimethylsilyl)aryl triflates, and 3-hydroxy-4-aminothiadiazoles leads to the selective formation of 3-amino-substituted benzo[d]isothiazoles. Variation of the substitution pattern of the aryne precursor, and of the thiadiazole, is possible, with the target heterocycles being obtained in good to excellent yields. In all cases, use of 3-hydroxy-4-aminothiadiazoles leads to incorporation of the amino-substituent in the product heterocycle. |
| first_indexed | 2024-03-07T08:17:14Z |
| format | Journal article |
| id | oxford-uuid:713a227e-e1b0-41b7-a27a-6362075a09a2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:17:14Z |
| publishDate | 2015 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | oxford-uuid:713a227e-e1b0-41b7-a27a-6362075a09a22024-01-10T09:05:34ZAn aryne-based route to substituted benzoisothiazolesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:713a227e-e1b0-41b7-a27a-6362075a09a2EnglishSymplectic Elements at OxfordAmerican Chemical Society2015Chen, YWillis, MCThe combination of arynes, generated using fluoride from the corresponding 2-(trimethylsilyl)aryl triflates, and 3-hydroxy-4-aminothiadiazoles leads to the selective formation of 3-amino-substituted benzo[d]isothiazoles. Variation of the substitution pattern of the aryne precursor, and of the thiadiazole, is possible, with the target heterocycles being obtained in good to excellent yields. In all cases, use of 3-hydroxy-4-aminothiadiazoles leads to incorporation of the amino-substituent in the product heterocycle. |
| spellingShingle | Chen, Y Willis, MC An aryne-based route to substituted benzoisothiazoles |
| title | An aryne-based route to substituted benzoisothiazoles |
| title_full | An aryne-based route to substituted benzoisothiazoles |
| title_fullStr | An aryne-based route to substituted benzoisothiazoles |
| title_full_unstemmed | An aryne-based route to substituted benzoisothiazoles |
| title_short | An aryne-based route to substituted benzoisothiazoles |
| title_sort | aryne based route to substituted benzoisothiazoles |
| work_keys_str_mv | AT cheny anarynebasedroutetosubstitutedbenzoisothiazoles AT willismc anarynebasedroutetosubstitutedbenzoisothiazoles AT cheny arynebasedroutetosubstitutedbenzoisothiazoles AT willismc arynebasedroutetosubstitutedbenzoisothiazoles |