The ClC-5 knockout mouse model of Dent's disease has renal hypercalciuria and increased bone turnover.

The ClC-5 knockout mouse model of Dent's disease has renal hypercalciuria and increased bone turnover.

Dent's disease is a nephrolithiasis disorder associated with hypercalciuria and low molecular weight proteinuria that is caused by mutations in the voltage-gated chloride channel ClC-5. Because the exact cause of hypercalciuria in this disease is unknown and could come from a renal, intestinal,...

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Manylion Llyfryddiaeth
Prif Awduron:	Silva, I, Cebotaru, V, Wang, H, Wang, X, Wang, S, Guo, G, Devuyst, O, Thakker, R, Guggino, W, Guggino, SE
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2003

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gan: Wang, S, et al.
Cyhoeddwyd: (2000)

STIM1fl/fl Ksp-Cre Mouse has Impaired Renal Water Balance
gan: Liudmila Cebotaru, et al.
Cyhoeddwyd: (2016-06-01)

Intra-renal and subcellular distribution of the human chloride channel, CLC-5, reveals a pathophysiological basis for Dent's disease.
gan: Devuyst, O, et al.
Cyhoeddwyd: (1999)

Comparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5.
gan: Jouret, F, et al.
Cyhoeddwyd: (2004)

Mutational analysis of CLC-5, cofilin and CLC-4 in patients with Dent's disease.
gan: Wu, F, et al.
Cyhoeddwyd: (2009)

Dent's disease.
gan: Devuyst, O, et al.
Cyhoeddwyd: (2010)

CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease.
gan: Reed, A, et al.
Cyhoeddwyd: (2010)

Dent's disease
gan: Thakker Rajesh V, et al.
Cyhoeddwyd: (2010-10-01)

ROLE OF A VOLTAGE-GATED CHLORIDE-CHANNEL GENE CLC-5 IN HUMAN AND RAT HYPERCALCIURIA
gan: Scheinman, S, et al.
Cyhoeddwyd: (1995)

The CLC-5 2Cl-/H+ exchange transporter in endosomal function and Dent’s disease.
gan: Jonathan eLippiat, et al.
Cyhoeddwyd: (2012-11-01)

Genetic aspects of hypercalciuria
gan: Thakker, R
Cyhoeddwyd: (2005)

Isolated hypercalciuria with mutation in CLCN5: relevance to idiopathic hypercalciuria.
gan: Scheinman, S, et al.
Cyhoeddwyd: (2000)

Mutations associated with Dent’s disease affect gating and voltage dependence of the human anion/proton exchanger ClC-5
gan: Alexi eAlekov
Cyhoeddwyd: (2015-05-01)

Lentiviral vector mediated gene therapy for type I Dent disease ameliorates Dent disease-like phenotypes for three months in ClC-5 null mice
gan: Manish Kumar Yadav, et al.
Cyhoeddwyd: (2022-12-01)

TMEM9B Regulates Endosomal ClC-3 and ClC-4 Transporters
gan: Margherita Festa, et al.
Cyhoeddwyd: (2024-08-01)

Correcting the cystic fibrosis disease mutant, A455E CFTR.
gan: Liudmila Cebotaru, et al.
Cyhoeddwyd: (2014-01-01)

Characterization of Dent's disease mutations of CLC-5 reveals a correlation between functional and cell biological consequences and protein structure.
gan: Smith, A, et al.
Cyhoeddwyd: (2009)

Renal function in children with hypercalciuria
gan: N Tekin, et al.
Cyhoeddwyd: (1997-07-01)

Chloride/proton antiporters ClC3 and ClC5 support bone formation in mice
gan: Irina L. Tourkova, et al.
Cyhoeddwyd: (2024-06-01)

A Newly Cloned ClC-3 Isoform, ClC-3d, as well as ClC-3a Mediates Cd2+-Sensitive Outwardly Rectifying Anion Currents
gan: Toshiaki Okada, et al.
Cyhoeddwyd: (2014-02-01)

Genetic Ablation of the ClC-2 Cl- Channel Disrupts Mouse Gastric Parietal Cell Acid Secretion.
gan: Meghali P Nighot, et al.
Cyhoeddwyd: (2015-01-01)

Molecular pathology of renal chloride channels in Dent's disease and Bartter's syndrome.
gan: Thakker, R
Cyhoeddwyd: (2000)

Structure of the human ClC-1 chloride channel.
gan: Kaituo Wang, et al.
Cyhoeddwyd: (2019-04-01)

Renal Tubular Impairment in Children with Idiopathic Hypercalciuria
gan: Sylva Skálová, et al.
Cyhoeddwyd: (2006-01-01)

Syntaxin 8 and the Endoplasmic Reticulum Processing of ΔF508-CFTR
gan: Inna Sabirzhanova, et al.
Cyhoeddwyd: (2018-11-01)

Physiology and pathophysiology of ClC-K/barttin channels
gan: Christoph eFahlke, et al.
Cyhoeddwyd: (2010-11-01)

The dimerization equilibrium of a ClC Cl−/H+ antiporter in lipid bilayers
gan: Rahul Chadda, et al.
Cyhoeddwyd: (2016-08-01)

Idiopathic hypercalciuria
gan: Joanna Milart, et al.
Cyhoeddwyd: (2016-03-01)

Dent's disease.
gan: Neild, G, et al.
Cyhoeddwyd: (2005)

The CFTR-Associated Ligand Arrests the Trafficking of the Mutant ΔF508 CFTR Channel in the ER Contributing to Cystic Fibrosis
gan: Emily Bergbower, et al.
Cyhoeddwyd: (2018-01-01)

Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation
gan: Julia Schewe, et al.
Cyhoeddwyd: (2019-11-01)

New insights into the mechanism of NO3- selectivity in the human kidney chloride channel ClC-Ka and the CLC protein family
gan: Lagostena, L, et al.
Cyhoeddwyd: (2019)

Backbone amides are determinants of Cl− selectivity in CLC ion channels
gan: Lilia Leisle, et al.
Cyhoeddwyd: (2022-12-01)

Regulation of ClC-2 Activity by SPAK and OSR1
gan: Jamshed Warsi, et al.
Cyhoeddwyd: (2014-10-01)

Is the renal kallikrein-kinin system a factor that modulates hypercalciuria?
gan: Armando Luis Negri
Cyhoeddwyd: (2017-01-01)

Familial idiopathic hypercalciuria
gan: N Buyan, et al.
Cyhoeddwyd: (1988-07-01)

Hypercalciuria in Postmenopausal Osteoporosis
gan: Ayfer Kanberoğlu, et al.
Cyhoeddwyd: (2004-06-01)

Genetic analysis of the hypercalciuric rat, a model for human idiopathic hypercalciuria.
gan: Hoopes, R, et al.
Cyhoeddwyd: (1996)

Mutations of CLCN5 in Japanese children with idiopathic low molecular weight proteinuria, hypercalciuria and nephrocalcinosis.
gan: Akuta, N, et al.
Cyhoeddwyd: (1997)

Dent's like proximal renal tubular disorder in a First Nations' kindred.
gan: Hadad, K, et al.
Cyhoeddwyd: (1997)