Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.

Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.

Mouse pancreatic β- and α-cells are equipped with voltage-gated Na(+) currents that inactivate over widely different membrane potentials (half-maximal inactivation (V0.5) at -100 mV and -50 mV in β- and α-cells, respectively). Single-cell PCR analyses show that both α- and β-cells have Nav1.3 (Scn3)...

Full description

Bibliographic Details
Main Authors: Zhang, Q, Chibalina, M, Bengtsson, M, Groschner, L, Ramracheya, R, Rorsman, N, Leiss, V, Nassar, M, Welling, A, Gribble, F, Reimann, F, Hofmann, F, Wood, J, Ashcroft, F, Rorsman, P
Format: Journal article
Language:English
Published: Wiley 2014

Similar Items