Colorectal tumourigenesis in carriers of the APC I1307K variant: lone gunman or conspiracy?
The APC I1307K allele is believed to predispose to multiple colorectal tumours because the change at the nucleotide level-A(3)TA(4) to A(8)-creates a hypermutable site. Slippage of the A(8) tract undoubtedly occurs more often than expected in the tumours of I1307K carriers, but many of these tumours...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2003
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