Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation

Medulloblastoma is the most common malignant brain tumour in children. Genomic studies have identified distinct disease subgroups: wnt/wingless (WNT), sonic hedgehog (SHH), and non-WNT/non-SHH, comprising group 3 and group 4. Alterations in WNT and SHH signalling form the pathogenetic basis for thei...

Bibliografski detalji
Glavni autori:	Chen, Z, Ioris, RM, Richardson, S, Van Ess, AN, Vendrell, I, Kessler, BM, Buffa, FM, Busino, L, Clifford, SC, Bullock, AN, D'Angiolella, V
Format:	Journal article
Jezik:	English
Izdano:	Springer Nature 2022

Slični predmeti

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development
od: D'Angiolella, V, i dr.
Izdano: (2016)

Cyclin F–EXO1 axis controls cell cycle–dependent execution of double-strand break repair
od: Yang, H, i dr.
Izdano: (2024)

Archives, Innovation, and the Neomorphic Cyclops
od: Anatole Mori
Izdano: (2017-03-01)

Decreased Expression of CoREST1 and CoREST2 Together with LSD1 and HDAC1/2 during Neuronal Differentiation.
od: Julián Esteban Sáez, i dr.
Izdano: (2015-01-01)

Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression
od: Lei Du, i dr.
Izdano: (2020-10-01)

Correction: Decreased Expression of CoREST1 and CoREST2 Together with LSD1 and HDAC1/2 during Neuronal Differentiation.
od: PLOS ONE Staff
Izdano: (2015-01-01)

Targeting the ubiquitylation and ISGylation machinery for the treatment of COVID-19
od: Vere, G, i dr.
Izdano: (2022)

Kbtbd11 contributes to adipocyte homeostasis through the activation of upstream stimulatory factor 1
od: Kazuhisa Watanabe, i dr.
Izdano: (2019-11-01)

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis
od: Paola Infante, i dr.
Izdano: (2018-03-01)

Kbtbd11 gene expression in adipose tissue increases in response to feeding and affects adipocyte differentiation
od: Kazuhisa Watanabe, i dr.
Izdano: (2019-07-01)

UBE2G1 governs the destruction of cereblon neomorphic substrates
od: Gang Lu, i dr.
Izdano: (2018-09-01)

REST and CoREST modulate neuronal subtype specification, maturation and maintenance.
od: Joseph J Abrajano, i dr.
Izdano: (2009-12-01)

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
od: Jay H. Kalin, i dr.
Izdano: (2018-01-01)

Human platelet protein ubiquitylation and changes following GPVI activation
od: Unsworth, AJ, i dr.
Izdano: (2018)

Imprinting at the KBTBD6 locus involves species-specific maternal methylation and monoallelic expression in livestock animals
od: Jinsoo Ahn, i dr.
Izdano: (2023-10-01)

Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies
od: Carman K. M. Ip, i dr.
Izdano: (2018-11-01)

MicroRNA Targeting of CoREST Controls Polarization of Migrating Cortical Neurons
od: Marie-Laure Volvert, i dr.
Izdano: (2014-05-01)

KBTBD7 promotes non‐small cell lung carcinoma progression by enhancing ubiquitin‐dependent degradation of PTEN
od: Zifang Zou, i dr.
Izdano: (2022-12-01)

AVERON notebook to discover actionable cancer vulnerabilities enabled by neomorph protein-protein interactions
od: Hongyue Chen, i dr.
Izdano: (2024-06-01)

The CoREST complex regulates multiple histone modifications temporal-specifically in clock neurons
od: Pengfei Lv, i dr.
Izdano: (2024-07-01)

A developmental role for the chromatin-regulating CoREST complex in the cnidarian Nematostella vectensis
od: James M. Gahan, i dr.
Izdano: (2022-08-01)

Targeting the GFI1/1B—CoREST Complex in Acute Myeloid Leukemia
od: Maaike G. J. M. van Bergen, i dr.
Izdano: (2019-10-01)

Decoding histone ubiquitylation
od: Jennifer J. Chen, i dr.
Izdano: (2022-08-01)

Structural basis for recruitment of DAPK1 to the KLHL20 E3 ligase
od: Chen, Z, i dr.
Izdano: (2019)

Cks1 activates transcription by binding to the ubiquitylated proteasome.
od: Holic, R, i dr.
Izdano: (2010)

A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis
od: Yanzhe Gao, i dr.
Izdano: (2016-07-01)

Protocol to discover actionable cancer vulnerabilities enabled by neomorph protein-protein interactions with the AVERON Notebook
od: Hongyue Chen, i dr.
Izdano: (2024-12-01)

Multidimensional quantitative phenotypic and molecular analysis reveals neomorphic behaviors of p53 missense mutants
od: Anasuya Pal, i dr.
Izdano: (2023-09-01)

Lymphocyte-Specific Function of the DNA Polymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles
od: Iliana Siamishi, i dr.
Izdano: (2020-06-01)

Targeting the Ubiquitylation and ISGylation Machinery for the Treatment of COVID-19
od: George Vere, i dr.
Izdano: (2022-02-01)

Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation.
od: Joseph J Abrajano, i dr.
Izdano: (2009-11-01)

The CoREST/REST Repressor Is both Necessary and Inimical for Expression of Herpes Simplex Virus Genes
od: Guoying Zhou, i dr.
Izdano: (2011-03-01)

Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex
od: Yun Song, i dr.
Izdano: (2020-02-01)

Core-rod myopathy due to a novel mutation in BTB/POZ domain of KBTBD13 manifesting as late onset LGMD
od: Matteo Garibaldi, i dr.
Izdano: (2018-09-01)

Regulation of DNA repair by ubiquitylation.
od: Dianov, G, i dr.
Izdano: (2011)

Protein Ubiquitylation in Pancreatic Cancer
od: Thomas Bonacci, i dr.
Izdano: (2010-01-01)

Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma
od: Tilman L. B. Hölting, i dr.
Izdano: (2022-10-01)

E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition
od: Burdova, K, i dr.
Izdano: (2019)

Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila
od: Mai Takakura, i dr.
Izdano: (2021-01-01)

ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin
od: Lifang Li, i dr.
Izdano: (2017-09-01)