Exome-derived adiponectin-associated variants implicate obesity and lipid biology

Exome-derived adiponectin-associated variants implicate obesity and lipid biology

Circulating levels of adiponectin, an adipocyte-secreted protein associated with cardiovascular and metabolic risk, are highly heritable. To gain insights into the biology that regulates adiponectin levels, we performed an exome array meta-analysis of 265,780 genetic variants in 67,739 individuals o...

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Main Authors: Spracklen, CN, Karaderi, T, Yaghootkar, H, Schurmann, C, Fine, RS, Kutalik, Z, Preuss, MH, Lu, Y, Wittemans, LBL, Adair, LS, Allison, M, Amin, N, Auer, PL, Bartz, TM, Blüher, M, Boehnke, M, Borja, JB, Bork-Jensen, J, Broer, L, Chasman, DI, Chen, Y-DI, Chirstofidou, P, Demirkan, A, Van Duijn, CM, Feitosa, MF, Garcia, ME, Graff, M, Grallert, H, Grarup, N, Guo, X, Haesser, J, Hansen, T, Harris, TB, Highland, HM, Hong, J, Ikram, MA, Ingelsson, E, Jackson, R, Jousilahti, P, Kähönen, M, Kizer, JR, Kovacs, P, Kriebel, J, Laakso, M, Lange, LA, Lehtimäki, T, Li, J, Li-Gao, R, Lind, L, Luan, J, Lyytikäinen, L-P, Macgregor, S, Mackey, DA, Mahajan, A, Mangino, M, Männistö, S, McCarthy, MI, McKnight, B, Medina-Gomez, C, Meigs, JB, Molnos, S, Mook-Kanamori, D, Morris, AP, De Mutsert, R, Nalls, MA, Nedeljkovic, I, North, KE, Pennell, CE, Pradhan, AD, Province, MA, Raitakari, OT, Raulerson, CK, Reiner, AP, Ridker, PM, Ripatti, S, Roberston, N, Rotter, JI, Salomaa, V, Sandoval-Zárate, AA, Sitlani, CM, Spector, TD, Strauch, K, Stumvoll, M, Taylor, KD, Thuesen, B, Tönjes, A, Uitterlinden, AG, Venturini, C, Walker, M, Wang, CA, Wang, S, Wareham, NJ, Willems, SM, Van Dijk, K, Wilson, JG, Wu, Y, Yao, J, Young, KL, Langenberg, C, Frayling, TM, Kilpeläinen, TO, Lindgren, CM, Loos, RJF, Mohlke, KL
Format: Journal article
Language:English
Published: Elsevier 2019

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