Metallo supramolecular cylinders inhibit HIV-1 TAR-TAT complex formation and viral replication in cellulo
Shape-selective recognition of nucleic acid structures by supramolecular drugs offers the potential to treat disease. The Trans Activation Response (TAR) region is a region of high secondary structure within the human immunodeficiency virus-1 (HIV-1) RNA that complexes with the virus-encoded Transac...
| Main Authors: | , , , , |
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| Format: | Journal article |
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Springer Nature
2018
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| _version_ | 1797075331683713024 |
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| author | Cardo, L Nawroth, I Cail, P McKeating, J Hannon, M |
| author_facet | Cardo, L Nawroth, I Cail, P McKeating, J Hannon, M |
| author_sort | Cardo, L |
| collection | OXFORD |
| description | Shape-selective recognition of nucleic acid structures by supramolecular drugs offers the potential to treat disease. The Trans Activation Response (TAR) region is a region of high secondary structure within the human immunodeficiency virus-1 (HIV-1) RNA that complexes with the virus-encoded Transactivator protein (TAT) and regulates viral transcription. Herein, we explore different metallo-supramolecular triple stranded helicates (cylinders) that target the TAR bulge motif and inhibit the formation of TAR-TAT complexes and HIV infection. Cylinders that incorporate Ni(II) and Ru(II) showed the most potent anti-viral activity with limited evidence of cellular cytotoxicity. These metallo-supramolecular compounds provide an exciting avenue for developing a new class of anti-viral agents. |
| first_indexed | 2024-03-06T23:48:59Z |
| format | Journal article |
| id | oxford-uuid:71f197ce-2c58-4eb6-bf7c-0519edd98916 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T23:48:59Z |
| publishDate | 2018 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:71f197ce-2c58-4eb6-bf7c-0519edd989162022-03-26T19:46:57ZMetallo supramolecular cylinders inhibit HIV-1 TAR-TAT complex formation and viral replication in celluloJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:71f197ce-2c58-4eb6-bf7c-0519edd98916Symplectic Elements at OxfordSpringer Nature2018Cardo, LNawroth, ICail, PMcKeating, JHannon, MShape-selective recognition of nucleic acid structures by supramolecular drugs offers the potential to treat disease. The Trans Activation Response (TAR) region is a region of high secondary structure within the human immunodeficiency virus-1 (HIV-1) RNA that complexes with the virus-encoded Transactivator protein (TAT) and regulates viral transcription. Herein, we explore different metallo-supramolecular triple stranded helicates (cylinders) that target the TAR bulge motif and inhibit the formation of TAR-TAT complexes and HIV infection. Cylinders that incorporate Ni(II) and Ru(II) showed the most potent anti-viral activity with limited evidence of cellular cytotoxicity. These metallo-supramolecular compounds provide an exciting avenue for developing a new class of anti-viral agents. |
| spellingShingle | Cardo, L Nawroth, I Cail, P McKeating, J Hannon, M Metallo supramolecular cylinders inhibit HIV-1 TAR-TAT complex formation and viral replication in cellulo |
| title | Metallo supramolecular cylinders inhibit HIV-1 TAR-TAT complex formation and viral replication in cellulo |
| title_full | Metallo supramolecular cylinders inhibit HIV-1 TAR-TAT complex formation and viral replication in cellulo |
| title_fullStr | Metallo supramolecular cylinders inhibit HIV-1 TAR-TAT complex formation and viral replication in cellulo |
| title_full_unstemmed | Metallo supramolecular cylinders inhibit HIV-1 TAR-TAT complex formation and viral replication in cellulo |
| title_short | Metallo supramolecular cylinders inhibit HIV-1 TAR-TAT complex formation and viral replication in cellulo |
| title_sort | metallo supramolecular cylinders inhibit hiv 1 tar tat complex formation and viral replication in cellulo |
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