Electrophysiological and metabolic characterization of single beta-cells and islets from diabetic GK rats.

Electrophysiological and metabolic characterization of single beta-cells and islets from diabetic GK rats.

We have used the whole-cell recording technique to determine whether ATP-sensitive potassium (K[ATP]) currents, voltage-dependent Ca2+ currents, and exocytosis are different in single beta-cells from pancreatic islets of Goto-Kakizaki (GK) rats, a novel model of NIDDM, and normal rats. In addition,...

書誌詳細
主要な著者:	Hughes, S, Faehling, M, Thorneley, C, Proks, P, Ashcroft, F, Smith, P
フォーマット:	Journal article
言語:	English
出版事項:	1998

類似資料

Metformin restores electrophysiology of small conductance calcium-activated potassium channels in the atrium of GK diabetic rats
著者:: Xi Fu, 等
出版事項: (2018-04-01)

Electrophysiology of the pancreatic beta-cell.
著者:: Ashcroft, F, 等
出版事項: (1989)

DIFFERENT TYPES OF MEMBRANE RETRIEVAL IN SINGLE-MOUSE PANCREATIC BETA-CELLS
著者:: Proks, P, 等
出版事項: (1995)

Excessive islet NO generation in type 2 diabetic GK rats coincides with abnormal hormone secretion and is counteracted by GLP-1.
著者:: Albert Salehi, 等
出版事項: (2008-05-01)

Excessive Islet NO Generation in Type 2 Diabetic GK Rats Coincides with Abnormal Hormone Secretion and Is Counteracted by GLP-1
出版事項: (2008-01-01)

Excessive Islet NO Generation in Type 2 Diabetic GK Rats Coincides with Abnormal Hormone Secretion and Is Counteracted by GLP-1.
著者:: Albert Salehi, 等
出版事項: (2008-01-01)

CA-INDEPENDENT STIMULATION OF EXOCYTOSIS BY GTP IN SINGLE-MOUSE PANCREATIC BETA-CELLS
著者:: Proks, P, 等
出版事項: (1994)

Effects of divalent cations on exocytosis and endocytosis from single mouse pancreatic beta-cells.
著者:: Proks, P, 等
出版事項: (1995)

Modulation of tolbutamide sensitivity of K-ATP currents in mouse pancreatic beta-cells by intracellular nucleotides and magnesium
著者:: Faehling, M, 等
出版事項: (1996)

Correction: Excessive Islet NO Generation in Type 2 Diabetic GK Rats Coincides with Abnormal Hormone Secretion and Is Counteracted by GLP-1
出版事項: (2008-01-01)

Correction: Excessive Islet NO Generation in Type 2 Diabetic GK Rats Coincides with Abnormal Hormone Secretion and Is Counteracted by GLP-1.
著者:: Albert Salehi, 等
出版事項: (2008-01-01)

Correction: Excessive Islet NO Generation in Type 2 Diabetic GK Rats Coincides with Abnormal Hormone Secretion and Is Counteracted by GLP-1
出版事項: (2008-01-01)

Correction: Excessive Islet NO Generation in Type 2 Diabetic GK Rats Coincides with Abnormal Hormone Secretion and Is Counteracted by GLP-1.
著者:: Albert Salehi, 等
出版事項: (2008-01-01)

Higher maternal than paternal inheritance of diabetes in GK rats.
著者:: Gauguier, D, 等
出版事項: (1994)

Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat.
著者:: Grégory Lacraz, 等
出版事項: (2009-09-01)

Exocytosis in isolated mouse pancreatic beta-cells
著者:: Ashcroft, F, 等
出版事項: (1996)

Mutations in seipin are unlikely to cause diabetes in the goto-kakizaki (GK) diabetic rat
著者:: Kaisaki, P, 等
出版事項: (2002)

Heterogeneity of beta-cell secretion. Possible involvement of K-ATP channels.
著者:: Faehling, M, 等
出版事項: (1997)

Construction of congenic lines for the locus Nidd/gk1 controlling glucose tolerance in the GK rat.
著者:: Wallis, R, 等
出版事項: (1999)

Functional identification of islet cell types by electrophysiological fingerprinting
著者:: Briant, L, 等
出版事項: (2017)

GLUCOSE INHIBITS POTASSIUM CHANNEL ACTIVITY IN SINGLE-RAT PANCREATIC-ISLET CELLS
著者:: Ashcroft, F, 等
出版事項: (1985)

Quantal analysis of 5-hydroxytryptamine release from mouse pancreatic beta-cells.
著者:: Smith, P, 等
出版事項: (1999)

CORRELATION OF INTERNAL CALCIUM TRANSIENTS, EXOCYTOSIS AND THE RELEASE OF GRANULE CONTENTS IN PANCREATIC BETA-CELLS
著者:: Smith, P, 等
出版事項: (1994)

Alterations in Energy Metabolism, Mitochondrial Function and Redox Homeostasis in GK Diabetic Rat Tissues Treated with Aspirin
著者:: Annie John, 等
出版事項: (2022-01-01)

Effects of Danggui Buxue decoction on host gut microbiota and metabolism in GK rats with type 2 diabetes
著者:: Wen-kai Wang, 等
出版事項: (2022-10-01)

Carbohydrate response element‐binding protein (ChREBP) mediates decreased SNAP25 expression in islets from diabetic Goto‐Kakizaki (GK) rats
著者:: Anyi Hu, 等
出版事項: (2024-11-01)

GENETIC DISSECTION ON NON-INSULIN-DEPENDENT DIABETES IN THE GOTO-KAKIZAKI (GK) RAT
著者:: Gauguier, D, 等
出版事項: (1995)

Modification of K-ATP channels in pancreatic beta-cells by trypsin.
著者:: Proks, P, 等
出版事項: (1993)

EXOCYTOSIS MONITORED BY SIMULTANEOUS MEASUREMENT OF CELL CAPACITANCE AND 5-HT RELEASE IN ISOLATED MOUSE PANCREATIC BETA-CELLS
著者:: Smith, P, 等
出版事項: (1994)

Multiple diabetes QTL on rat chromosome 1 defined by GK rat congenic lines
著者:: Collins, S, 等
出版事項: (2002)

EFFECTS OF DIVALENT-CATIONS ON SECRETION FROM ISOLATED MOUSE PANCREATIC BETA-CELLS
著者:: Ashcroft, F, 等
出版事項: (1994)

EFFECTS OF TRYPSIN ON ATP-DEPENDENT-K+ CHANNELS FROM PANCREATIC BETA-CELLS
著者:: Proks, P, 等
出版事項: (1992)

Differential metabolic and nucleotide sensitivity of beta-cell and cardiac K-ATP channels
著者:: Vedovato, N, 等
出版事項: (2018)

Effect of Dietary Acrylamide Exposure on Blood Glucose Metabolism and Organ Functions of Type 2 Diabetic GK Rats
著者:: XIE Yiting, PENG Fei, LOU Aihua, SHEN Qingwu, CHEN Jie, QUAN Wei
出版事項: (2023-04-01)

Integrable deformations of the Gk1×Gk2/Gk1+k2 coset CFTs
著者:: Konstantinos Sfetsos, 等
出版事項: (2018-02-01)

Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat.
著者:: Gauguier, D, 等
出版事項: (1996)

Characteristics of Gastric Microbiota in GK Rats with Spontaneous Diabetes: A Comparative Study
著者:: Kang X, 等
出版事項: (2020-04-01)

Pancreatic beta cells express the fetal islet hormone gastrin in rodent and human diabetes
著者:: Dahan, T, 等
出版事項: (2016)

Exercise alleviates diabetic complications by inhibiting oxidative stress-mediated signaling cascade and mitochondrial metabolic stress in GK diabetic rat tissues
著者:: Annie John, 等
出版事項: (2022-12-01)

Modulation of gating of the cloned beta-cell K-ATP channel
著者:: Proks, P, 等
出版事項: (1998)