Asymmetric synthesis of beta-fluoroaryl-beta-amino acids
The conjugate addition of lithium (R)-N-benzyl-N-(α-methylbenzyl) amide to a range of β-fluoroaryl-α,β-unsaturated esters gave the corresponding β-amino esters with high diastereoselectivity and in good isolated yields. Sequential treatment of the resultant β-fluoroaryl-β- amino esters under optimis...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2012
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