Asymmetric synthesis of beta-fluoroaryl-beta-amino acids

Asymmetric synthesis of beta-fluoroaryl-beta-amino acids

The conjugate addition of lithium (R)-N-benzyl-N-(α-methylbenzyl) amide to a range of β-fluoroaryl-α,β-unsaturated esters gave the corresponding β-amino esters with high diastereoselectivity and in good isolated yields. Sequential treatment of the resultant β-fluoroaryl-β- amino esters under optimis...

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Autors principals:	Davies, S, Fletcher, A, Lv, L, Roberts, P, Thomson, J
Format:	Journal article
Idioma:	English
Publicat:	2012

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