A helix heterodimer in a lipid bilayer: prediction of the structure of an integrin transmembrane domain via multiscale simulations.

Dimerization of transmembrane (TM) α helices of membrane receptors plays a key role in signaling. We show that molecular dynamics simulations yield models of integrin TM helix heterodimers, which agree well with available NMR structures. We use a multiscale simulation approach, combining coarse-grai...

詳細記述

書誌詳細
主要な著者: Kalli, A, Hall, B, Campbell, I, Sansom, MS
フォーマット: Journal article
言語:English
出版事項: 2011