Design, synthesis and evaluation of molecularly targeted hypoxia-activated prodrugs

Regions of insufficient oxygen supply-hypoxia-occur in diverse contexts across biology in both healthy and diseased organisms. The difference in the chemical environment between a hypoxic biological system and one with normal oxygen levels provides an opportunity for targeting compound delivery to h...

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Bibliographic Details
Main Authors: O'Connor, L, Cazares-Körner, C, Saha, J, Evans, C, Stratford, MR, Hammond, E, Conway, S
Format: Journal article
Language:English
Published: Nature Publishing Group 2016