Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD.

Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD.

PURPOSE: Exudative AMD (wet AMD) is treated by monthly injection into the eye of anti-VEGF proteins. VEGF is alternatively spliced to produce numerous isoforms that differ in angiogenic activity. Serine-rich protein kinase-1 (SRPK1) has been identified as a regulator of pro-angiogenic VEGF splicing...

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Bibliographic Details
Main Authors: Gammons, M, Fedorov, O, Ivison, D, Du, C, Clark, T, Hopkins, C, Hagiwara, M, Dick, A, Cox, R, Harper, S, Hancox, J, Knapp, S, Bates, DO
Format: Journal article
Language:English
Published: 2013

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