Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD.
PURPOSE: Exudative AMD (wet AMD) is treated by monthly injection into the eye of anti-VEGF proteins. VEGF is alternatively spliced to produce numerous isoforms that differ in angiogenic activity. Serine-rich protein kinase-1 (SRPK1) has been identified as a regulator of pro-angiogenic VEGF splicing...
Հիմնական հեղինակներ: | Gammons, M, Fedorov, O, Ivison, D, Du, C, Clark, T, Hopkins, C, Hagiwara, M, Dick, A, Cox, R, Harper, S, Hancox, J, Knapp, S, Bates, DO |
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Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
2013
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