Similar reduction of first- and second-phase B-cell responses at three different glucose levels in type II diabetes and the effect of gliclazide therapy.

To characterize the abnormal B-cell response to glucose in type II diabetes, five diet-treated diabetic and six weight-matched non-diabetic subjects were studied using the hyperglycemic clamp technique on three separate days at glycemic levels of 7.5, 10 and 15 mmol/L for 150 minutes with assessment...

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Bibliographic Details
Main Authors: Hosker, J, Rudenski, A, Burnett, M, Matthews, DR, Turner, R
Format: Journal article
Language:English
Published: 1989