Δ9-tetrahydrocannabinol and 2-AG decreases neurite outgrowth and differentially affects ERK1/2 and Akt signaling in hiPSC-derived cortical neurons

Endocannabinoids regulate different aspects of neurodevelopment. In utero exposure to the exogenous psychoactive cannabinoid Δ9-tetrahydrocannabinol (Δ9-THC), has been linked with abnormal cortical development in animal models. However, much less is known about the actions of end...

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Bibliographic Details
Main Authors: Shum, C, Dutan, L, Annuario, E, Warre-Cornish, K, Taylor, SE, Taylor, RD, Andreae, LC, Buckley, NJ, Price, J, Bhattacharyya, S, Srivastava, DP
Format: Journal article
Language:English
Published: Elsevier 2020