Access to a guanacastepene and cortistatin-related skeleton via ethynyl lactone Ireland−Claisen rearrangement and transannular (4 + 3)-cycloaddition of an azatrimethylenemethane diyl
Heating a 2,5-furanocyclic (2-azidoethyl)allene initiates a cascade reaction comprising azide–allene cycloaddition, loss of nitrogen, and azatrimethylenemethane (ATMM) diyl–furan transannular (4+3)-cycloaddition. The major product of this reaction contains the pentacyclic core common to guanacastepe...
| Main Authors: | , , , |
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| Format: | Journal article |
| Published: |
American Chemical Society
2017
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