Transcriptional interference and termination between duplicated alpha-globin gene constructs suggests a novel mechanism for gene regulation.

The interesting possibility that transcriptional interference can occur between eukaryotic genes was raised by studies on the avian leukosis retrovirus (ALV) which showed that deletion of the promoter in the 5' long terminal repeat (LTR) activates the 3' LTR promoter, linked to a downstrea...