Refining the Amsterdam Criteria and Bethesda Guidelines: testing algorithms for the prediction of mismatch repair mutation status in the familial cancer clinic.

PURPOSE: Hereditary nonpolyposis colon cancer (HNPCC) is a Mendelian dominant syndrome of bowel, endometrial, and other cancers and results from germline mutations in mismatch repair (MMR) genes. HNPCC is now best diagnosed on molecular grounds using MMR mutation screening, aided by microsatellite i...

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Bibliographic Details
Main Authors:	Lipton, L, Johnson, V, Cummings, C, Fisher, S, Risby, P, Eftekhar Sadat, A, Cranston, T, Izatt, L, Sasieni, P, Hodgson, S, Thomas, H, Tomlinson, I
Format:	Journal article
Language:	English
Published:	2004

Refining the Amsterdam Criteria and Bethesda Guidelines: testing algorithms for the prediction of mismatch repair mutation status in the familial cancer clinic.

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