Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.

Inhibition of the hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD or EGLN enzymes) is of interest for the treatment of anemia and ischemia-related diseases. Most PHD inhibitors work by binding to the single ferrous ion and competing with 2-oxoglutarate (2OG) co-substrate for binding at the P...

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Bibliographic Details
Main Authors:	Yeoh, K, Chan, M, Thalhammer, A, Demetriades, M, Chowdhury, R, Tian, Y, Stolze, I, McNeill, L, Lee, M, Woon, E, Mackeen, M, Kawamura, A, Ratcliffe, P, Mecinović, J, Schofield, C
Format:	Journal article
Language:	English
Published:	2013

Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.

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