Novel mannosidase inhibitors probe glycoprotein degradation pathways in cells.

Multiple isoforms of mammalian alpha-mannosidases are active in the pathways of N-linked glycoprotein synthesis and catabolism. They differ in specificity, function and location within the cell and can be selectively inhibited by imino sugar monosaccharide mimics. Previously, a series of structurall...

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Detalhes bibliográficos
Principais autores: Butters, T, Alonzi, D, Kukushkin, N, Ren, Y, Blériot, Y
Formato: Journal article
Idioma:English
Publicado em: 2009