ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness

ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness

Aberrant activation of the hypoxia-inducible transcription factor HIF-1 and dysfunction of the tumor suppressor p53 have been reported to induce malignant phenotypes and therapy resistance of cancers. However, their mechanistic and functional relationship remains largely unknown. Here, we reveal a m...

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Autors principals: Koyasu, S, Horita, S, Saito, K, Kobayashi, M, Ishikita, H, Chow, CC, Kambe, G, Nishikawa, S, Menju, T, Morinibu, A, Okochi, Y, Tabuchi, Y, Onodera, Y, Takeda, N, Date, H, Semenza, GL, Hammond, EM, Harada, H
Format: Journal article
Idioma:English
Publicat: EMBO Press 2022

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