ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness
Aberrant activation of the hypoxia-inducible transcription factor HIF-1 and dysfunction of the tumor suppressor p53 have been reported to induce malignant phenotypes and therapy resistance of cancers. However, their mechanistic and functional relationship remains largely unknown. Here, we reveal a m...
Հիմնական հեղինակներ: | Koyasu, S, Horita, S, Saito, K, Kobayashi, M, Ishikita, H, Chow, CC, Kambe, G, Nishikawa, S, Menju, T, Morinibu, A, Okochi, Y, Tabuchi, Y, Onodera, Y, Takeda, N, Date, H, Semenza, GL, Hammond, EM, Harada, H |
---|---|
Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
EMBO Press
2022
|
Նմանատիպ նյութեր
-
ZBTB7A forms a heterodimer with ZBTB2 and inhibits ZBTB2 homodimerization required for full activation of HIF-1
: Kambe, G, և այլն
Հրապարակվել է: (2024) -
UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization
: Nakashima, R, և այլն
Հրապարակվել է: (2017) -
UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization
: Ryota Nakashima, և այլն
Հրապարակվել է: (2017-07-01) -
LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis
: Yeom, CJ, և այլն
Հրապարակվել է: (2016) -
ArfGAP with the SH3 Domain, Ankyrin Repeat and PH Domain 1 Inversely Regulates Programmed Death-Ligand 1 Through Negative Feedback of Phosphorylated Epithelial Growth Factor Receptor and Activation of Nuclear Factor-Kappa B in Non-Small Cell Lung Cancer
: Chiba N, և այլն
Հրապարակվել է: (2025-01-01)