Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells.

We generated a new Bmp2 conditional-knockout allele without a neo cassette that removes the Bmp2 gene from osteoblasts (Bmp2-cKO(ob)) using the 3.6Col1a1-Cre transgenic model. Bones of Bmp2-cKO(ob) mice are thinner, with increased brittleness. Osteoblast activity is reduced as reflected in a reduced...

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Bibliographic Details
Main Authors: Yang, W, Guo, D, Harris, M, Cui, Y, Gluhak-Heinrich, J, Wu, J, Chen, X, Skinner, C, Nyman, J, Edwards, J, Mundy, G, Lichtler, A, Kream, B, Rowe, D, Kalajzic, I, David, V, Quarles, D, Villareal, D, Scott, G, Ray, M, Liu, S, Martin, J, Mishina, Y, Harris, SE
Format: Journal article
Language:English
Published: 2013